[摘要]目的:观察100例脑出血患者应用雷尼替丁对并发上消化道出血的预防作用。方法:在常规治疗的基础上加用雷尼替丁100mg静滴,每日1~2次,共2周,其间观察有关上消化道出血的指标以及对病死率等的影响。结果:治疗组和对照组并发上消化道出血的发生率和急性期死亡率分别为2%、18%和19.2%、32.6%(P<0.01)。结论:雷尼替丁不仅可明显降低脑出血并发上消化道出血的发生率,而且可以改善急性期的预后。 Observe the Function of Ranitidine in Preventing Cerebral Hemorrhage that Complicate Stress Ulcer by Observing 100 cases Abstract: Objective: To study the efficency of Ranitine on preventing of upper gastrointestinal hemorrhage in cerebral hemorrhage.Method: 100 patients with cerebral hemorrhage received Renitidine 100 mg ivgtt gd or bid for 14 dags on the base of convent ional treatment anel obser vef the relative variables anel the effluence to ratal rate. Result: The uncidence rate and ratal rate during the acute time of the therapeutic group anal control group that complicate the upper gastrointestinal hemorrhage is 2%、18% and 19.2%,32.69%(p<0.01).Conclusion: Ranutudune not only can decrease the ratal of upper gastroinrestinal which is the complication of cerebral hemorrhage but also in proving the progrosis significantly during the acute time. Key words: Ranitidine; Cerebral hemorrhage; Upper gastrointestional hemorrhage 脑出血并发应激性溃疡致上消化道出血是一种常见而严重的并发症,主要表现为呕血,黑便或两者兼有,病情越重,发生率越高,有文献报道其发生率可达19.4%~48.28%[1]。且上消化道出血越早,预后越差,我院应用雷尼替丁预防脑出血并发上消化道出血,取得了满意效果。 1 材料和方法 1.2 方法 1.2.1 常规治疗组:常规治疗包括控制血压,控制脑水肿,降低颅内压,维持水电解质平衡,对症支持等治疗,14d为1疗程。 1.2.2 预防性治疗组:常规治疗+预防性治疗,在常规治疗组的基础上,均在开始治疗时加用雷尼替丁100mg,每天1~2次,加入10%葡萄糖中静滴,14d为1疗程。两组患者在治疗过程中均严格控制饮食,禁食肉类,并禁用维生素C至少2d以上。 1.3 统计学分析:采用卡方检验。 2 结果 表1 两组患者并发上消化道出血的比较(略) 注:两组间比较P<0.01 2.2 对预后的影响:在急性期治疗组死亡上18例(18%),对照组死亡34例(32.69%),组间比效具有显著性差异(P<0.01)。存活者不同程度偏瘫失语,痴呆,记忆力减退等后遗症的发生率分别为78%和82.7%,组间比较无显著性差异。 [参考文献]
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